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Clinical trials have shown that nanobody-based CAR-T therapies exhibit comparable efficacy to traditional single-chain variable fragment (scFv)-based CAR-T cells in treating hematologic malignancies (141, 142), and similar approaches are now being adapted for melanoma treatment (143, 144)

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Thus, model fit was assessed using the Comparative Fit Index, Root Mean Square Error of Approximation and Standardized Root Mean Square Residual as calculated by lavaan cfa function, and Gamma Hat as calculated by the moreFitIndices function from semTools (v0.52) in RStudio (v3.5.1)

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Melittins great tendency to trigger hemolysis and quick metabolism might represent a hurdle to employing BV